HIV/AIDS FDA Approved Drugs

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FDA Approved Drugs for HIV/AIDS

This section provides features up-to-date collection of FDA approved drugs used in the treatment of HIV/AIDS.

FDA Approved Drugs

Efavirenz / Emtricitabine / Tenofovir disoproxil fumarate

Brand Name: Atripla

Description: Atripla is a fixed-dose combination tablet containing three antiretroviral medications. One tablet of Atripla is equivalent to one tablet of efavirenz 600 mg, a non-nucleoside reverse transcriptase inhibitor (NNRTI), and one tablet of Truvada. Truvada is a fixed-dose combination tablet of two nucleoside reverse transcriptase inhibitors (NRTIs), emtricitabine 200 mg and tenofovir disoproxil fumarate (tenofovir DF) 300 mg. [#]

Enfuvirtide

Brand Name: Fuzeon

Description: Enfuvirtide is an inhibitor of the fusion of HIV-1 with CD4 cells. It is a linear 36-amino acid synthetic peptide with an acetylated N-terminus and a carboxamide C-terminus. It is composed of naturally occurring L-amino acid residues. [#]

Maraviroc

Brand Name: Selzentry

Description: Maraviroc, also known as Selzentry, is a chemokine receptor antagonist that acts as an entry inhibitor. It is designed to prevent HIV infection of CD4 cells by blocking chemokine receptor 5 (CCR5), a coreceptor necessary for HIV entry, from binding to HIV. [#]

Raltegravir

Brand Name: Isentress

Description: Raltegravir, also known as MK-0518, is a first-in-its-class oral integrase inhibitor. Inhibition of integrase prevents insertion of HIV DNA into the human DNA genome, thus blocking the ability of HIV to replicate. [#]

Delavirdine

Brand Name: Rescriptor

Description: Delavirdine mesylate is a bis(heteroaryl)piperazine (BHAP) derivative nonnucleoside reverse transcriptase inhibitor (NNRTI). [#]

Efavirenz

Brand Name: Sustiva

Description: Efavirenz, also known as EFV, is a benzoxazinone derivative non-nucleoside reverse transcriptase inhibitor (NNRTI). [#]

Etravirine

Brand Name: Intelence

Description: Etravirine, also known as Intelence or TMC125, is a diarylpyrimidine (DAPY) derivative with potent in vitro activity against HIV. [#]

In vitro, etravirine has equipotent activity against wild-type HIV and NNRTI-resistant variants that encode L100I, K103N, Y181C, Y188L, and G190A/S mutations. [#]

Nevirapine

Brand Name: Viramune

Description: Nevirapine is a dipyridodiazepine derivative non-nucleoside reverse transcriptase inhibitor (NNRTI). [#]

Abacavir

Brand Name: Ziagen

Description: Abacavir is a synthetic analogue of guanine, a naturally occurring purine nucleoside. It differs structurally from other reverse transcriptase inhibitors (didanosine, lamivudine, stavudine, zalcitabine, and zidovudine) in that it is a carbocyclic nucleoside analogue rather than a dideoxynucleoside analogue. [#]

Abacavir/Lamivudine

Brand Name: Epzicom

Description: Abacavir sulfate/lamivudine (Epzicom) is a fixed-dose tablet containing two nucleoside reverse transcriptase inhibitors (NRTIs): abacavir sulfate and lamivudine. Each tablet contains abacavir sulfate 600 mg and lamivudine 300 mg. [#]

Abacavir/Lamivudine/ Zidovudine

Brand Name: Trizivir

Description: Abacavir/lamivudine/zidovudine (Trizivir) is a fixed-dose tablet that contains three synthetic nucleoside analogues: abacavir sulfate, lamivudine, and zidovudine. Each tablet contains abacavir sulfate 300 mg, lamivudine 150 mg, and zidovudine 300 mg, each of which inhibits HIV-1 viral reverse transcriptase. [#]

Didanosine

Brand Name: Videx EC, Videx

Description: Didanosine, a synthetic antiretroviral agent, is a nucleoside reverse transcriptase inhibitor. [#] Didanosine, a synthetic antiretroviral agent, is a synthetic analogue of deoxyadenosine, a naturally occurring purine nucleoside. Didanosine differs from deoxyadenosine in that the 3'-hydroxyl group on the ribose moiety is replaced with hydrogen. [#]

Emtricitabine

Brand Name: Emtriva

Description: Emtricitabine, also referred to as FTC, is a nucleoside reverse transcriptase inhibitor (NRTI). Emtricitabine is the (-) enantiomer of a thio analogue of cytidine; it differs from other cytidine analogues by a fluorine in the 5 position. [#]

Emtricitabine/Tenofovir disoproxil fumarate

Brand Name: Truvada

Description: Truvada is a fixed-dose tablet containing two synthetic nucleoside analogues: emtricitabine and tenofovir disoproxil fumarate (DF). Each tablet contains emtricitabine 200 mg and tenofovir DF 300 mg. [#]

Lamivudine

Brand Name: Epivir

Description: Lamivudine, a synthetic antiretroviral agent, is a dideoxynucleoside reverse transcriptase inhibitor. Lamivudine is the negative enantiomer of a dideoxy analogue of cytidine and is structurally similar to zalcitabine (2',3'-dideoxycytidine, ddC). Lamivudine differs structurally from zalcitabine in that the 3'-carbon of the ribose ring is replaced with sulfur, forming an oxathiolane ring. The absence of a free 3'-hydroxy group on the oxathiolane ring results in the inability of lamivudine to form phosphodiester linkages at this position. Both the positive and negative enantiomers of 2',3'-dideoxy,3'-thiacytidine exhibit antiviral activity in vitro, but lamivudine appears to exhibit greater antiviral activity and to be considerably less cytotoxic than the positive enantiomer. [#]

Lamivudine/Zidovudine

Brand Name: Combivir

Description: Lamivudine/zidovudine is a fixed-dose tablet containing two synthetic nucleoside analogues: lamivudine and zidovudine. Each tablet contains 150 mg of lamivudine and 300 mg of zidovudine, each of which inhibits HIV-1 viral reverse transcriptase. [#]

Stavudine

Brand Name: Zerit

Description: Stavudine, a synthetic antiretroviral agent, is a dideoxynucleoside reverse transcriptase inhibitor. It is an analogue of thymidine, a naturally occurring pyrimidine nucleoside. It differs from thymidine in the 2'-3' double bond on the deoxyribose moiety and in the replacement of the 3'-hydroxyl group with hydrogen. The absence of a free 3'-hydroxyl group results in the inability of stavudine to form phosphodiester linkages at this position. [#]

Tenofovir disoproxil fumarate

Brand Name: Viread

Description: Tenofovir is an acyclic nucleotide analogue of deoxyadenosine 5'-monophosphate. Tenofovir disoproxil fumarate (tenofovir DF) is the water-soluble diester prodrug of the active ingredient tenofovir. Specifically, tenofovir DF is a fumaric acid salt of a bis-isopropxycarbonyloxymethyl ester derivative of tenofovir. [#]

Zidovudine

Brand Name: Retrovir

Description: Zidovudine, a synthetic antiretroviral agent, is a nucleoside reverse transcriptase inhibitor (NRTI), and an analogue of the naturally occurring nucleoside thymidine. [#] [#]

Acyclovir

Brand Name: Zovirax

Description: Acyclovir is a synthetic purine nucleoside analogue antiviral agent with activity against herpes simplex virus types 1 (HSV-1), genital herpes virus (HSV-2), and varicella-zoster virus (VZV). [#] [#]