HIV/AIDS Investigational Drugs

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Investigational Drugs for HIV/AIDS

This section provides features up-to-date collection of HIV/AIDS drugs which are under investigation.

Investigational Drugs

AMD070

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Description: AMD070, also known as AMD11070, is a type of medicine called a CXCR4 inhibitor. This type of medicine works by blocking the entry of HIV into cells.

PRO 140

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Description: PRO 140 is a type of medicine called an entry inhibitor. Entry inhibitors work by blocking the entry of HIV into human cells.

TNX-355

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Description: TNX-355 is a type of medicine called an entry inhibitor. Entry inhibitors work by blocking HIV from entering human cells.

Vicriviroc maleate

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Description: Vicriviroc, also known as SCH-D, is a type of medicine called an entry inhibitor. It is a drug also referred to as a chemokine antagonist. Entry inhibitors work by preventing HIV from infecting human cells.

GS 9137 (elvitegravir)

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Description: GS 9137 is a type of medicine called an integrase inhibitor. Integrase inhibitors work by blocking integrase, a protein that HIV needs to insert its viral genetic material into the genetic material of an infected cell.

BMS-378806

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Description: BMS-378806, also known as BMS-806, is a type of medicine called an entry inhibitor. Entry inhibitors work by blocking HIV from entering human cells.

C31G

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Description: C31G is a type of medicine called a microbicide. Microbicides are substances that protect the body from infection by microorganisms such as bacteria, viruses, and fungi. Microbicides work by either destroying the microbes or preventing them from establishing an infection.

Carbomer 974

Brand Name: BufferGel

Description: Carbomer 974, also known as BufferGel, is a type of medicine called a microbicide. Microbicides are substances that protect the body from microorganisms such as bacteria, viruses, and fungi. Microbicides work by either destroying the microbes or preventing them from establishing an infection.

Carrageenan

Brand Name: Carraguard

Description: Carrageenan is a chemical found in certain types of seaweed. Scientists have discovered that carrageenan can protect laboratory cells from becoming infected with many viruses, including HIV.

Cellulose sulfate

Brand Name: Ushercell

Description: Cellulose sulfate, or CS, is being studied as an experimental HIV microbicide called Ushercell. Microbicides are substances that protect the body from infection by microorganisms such as bacteria, viruses, and fungi. Microbicides work by either destroying the microbes or preventing them from establishing an infection.

Cyanovirin-N

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Description: Cyanovirin-N, also known as CV-N, is a type of medicine called a fusion inhibitor. Cyanovirin-N is being studied as a microbicide. Microbicides are substances that protect the body from infection by microorganisms such as bacteria, viruses, and fungi. Microbicides work by either destroying the microbes or preventing them from establishing an infection.

Hydroxyethyl cellulose

Brand Name: Cellulosize

Description: Hydroxyethyl cellulose, also known as HEC, is a gel-like substance that is a common ingredient in vaginal gels. Hydroxyethyl cellulose is not an active drug. Drugs to prevent and fight infection are mixed with hydroxyethyl cellulose so that they can be applied vaginally.

PRO 2000

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Description: PRO 2000, also known as PRO 2000/5, is a type of medicine called a microbicide. Microbicides are substances that protect the body from infection by microorganisms such as bacteria, viruses, and fungi. Microbicides work by either destroying the microbes or preventing them from establishing an infection.

SPL7013

Brand Name: VivaGel

Description: SPL7013, also known as VivaGel, is a type of medicine called a microbicide. Microbicides are substances that protect the body from infection by microorganisms such as bacteria, viruses, and fungi. Microbicides work by either destroying the microbes or preventing them from establishing an infection.

Tenofovir

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Description: Tenofovir gel, also known as PMPA gel, is a type of medicine called a microbicide. Microbicides are substances that protect the body from infection by microorganisms such as bacteria, viruses, and fungi. Microbicides work by either destroying the microbes or preventing them from establishing an infection.

UC-781

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Description: UC-781 is a type of medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is being studied as a microbicide. Microbicides are substances that protect the body from infection by microorganisms such as bacteria, viruses, and fungi. NNRTIs block reverse transcriptase, a protein that HIV needs to make more copies of itself. Microbicides work by either destroying the microbes or preventing them from establishing an infection.

Rilpivirine (TMC278)

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Description: TMC278 is a type of medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI). NNRTIs work by blocking reverse transcriptase, a protein that HIV needs to make more copies of itself.

Apricitabine

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Description:

Elvucitabine

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Description: Elvucitabine is a type of medicine called a nucleoside reverse transcriptase inhibitor (NRTI). NRTIs block reverse transcriptase, a protein that HIV needs to make more copies of itself.

KP-1461

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Description: KP-1461, also known as SN1461 and SN1212, is a type of medicine called a nucleoside analogue. KP-1461 works by introducing changes to HIV's genetic makeup that eventually kill the viral particles.

Racivir

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Description: Racivir, also known as RCV, is a type of medicine called a nucleoside reverse transcriptase inhibitor (NRTI). NRTIs work by blocking reverse transcriptase, a protein that HIV needs to make more copies of itself.

Bevirimat

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Description: Bevirimat is a type of medicine called a maturation inhibitor. It is the first drug in this class to be studied for the treatment of HIV. Maturation inhibitors work by blocking viral maturation, a late step in HIV development that is needed for the virus to become infectious.

Poly(I)-Poly(C12U)

Brand Name: Ampligen

Description: Poly(I)-poly(C12U), also known as Ampligen, is a type of antiviral drug called a biological response modifier. These types of drugs appear to restart human immune defenses against viruses and tumors.

Valproic acid

Brand Name: Depakene

Description: Valproic acid, also known as Depakene, is a type of medicine normally used to treat seizures and other nervous system problems. Valproic acid works against HIV by releasing the virus from resting cells so other anti-HIV medicines can attack it.